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J Virol. PubMed Charlton J, et al. PLoS One. PubMed Bonaccorsi-Riani E, et al. J Vis Exp. PubMed Kondo M, et al. J Immunol. PubMed Cook KD, et al. PubMed Espinosa JR, et al. Front Immunol. PubMed Chen S, et al. Nat Commun. PubMed Kubo M, et al. Oncol Rep. PubMed Cuburu N, et al. PubMed Nowill AE, et al. PubMed Wu J et al. PubMed Sema Kurtulus et al. PubMed Ying Zhang et al. Cancer cell. PubMed Kishore M et al. PubMed Winter C, et al.


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PubMed Wan X, et al. She played a seemingly lighthearted, but ultimately troubled New York City party girl who gets involved with a struggling writer played by George Peppard. Hepburn received her fourth Academy Award nomination for her work on the film.

For the rest of the s, Hepburn took on a variety of roles. She starred with Cary Grant in the romantic thriller Charade Playing the lead in the film version of the popular musical My Fair Lady , she went through one of the most famous metamorphoses of all time.

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As Eliza Doolittle, she played an English flower girl who becomes a high society lady. Taking on more dramatic fare, she starred a blind woman in the suspenseful tale Wait Until Dark opposite Alan Arkin. Her character used her wits to overcome the criminals that were harassing her.

This film brought her a fifth Academy Award nomination. That same year, Hepburn and her husband separated and later divorced. She married Italian psychiatrist Andrea Dotti in , and the couple had a son, Luca, in In the s and s, Hepburn worked sporadically. She starred opposite Sean Connery in Robin and Marian , a look at the central figures of the Robin Hood saga in their later years.

In , Hepburn co-starred with Ben Gazzara in the crime thriller Bloodline.


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Her last screen role was in Always directed by Steven Spielberg. Traveling the world, Hepburn tried to raise awareness about children in need. She understood too well what it was like to go hungry from her days in the Netherlands during the German Occupation. She won a special Academy Award for her humanitarian work in , but she did not live long enough to receive it.

Hepburn died on January 20, , at her home in Tolochenaz, Switzerland after a battle with colon cancer.